TheAspergillus nidulansF-box protein GrrA links SCF activity to meiosis
نویسندگان
چکیده
منابع مشابه
The Aspergillus nidulans F-box protein GrrA links SCF activity to meiosis.
Cellular differentiation relies on precise and controlled means of gene expression that act on several levels to ensure a flexible and defined spatio-temporal expression of a given gene product. In our aim to identify transcripts enriched during fruiting body formation of the homothallic ascomycete Aspergillus (Emericella) nidulans, the grrA gene could be identified in a negative subtraction hy...
متن کاملJFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation.
The p53 tumor suppressor plays a central role in integrating cellular responses to various stresses. Tight regulation of p53 is thus essential for the maintenance of genome integrity and normal cell proliferation. Currently, several ubiquitin ligases, including the single-subunit RING-finger types--MDM2, Pirh2, and COP1--and the HECT-domain type--ARF-BP1--have been reported to target p53 for de...
متن کاملThe SKP 1 - Cul 1 - F - box and Leucine - rich repeat protein 4 ( SCF - FbxL
Capucine Van Rechem, Joshua C. Black, Tarek A. Abbas, Andrew Allen, Claire A. Rinehart, GuoCheng Yuan, Anindya Dutta, and Johnathan R. Whetstine Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, 13 Street, Charlestown, MA 02129, USA. Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22...
متن کاملA novel route for F-box protein-mediated ubiquitination links CHIP to glycoprotein quality control.
In SCF (Skp1/Cullin/F-box protein) ubiquitin ligases, substrate specificity is conferred by a diverse array of F-box proteins. Only in fully assembled SCF complexes, it is believed, can substrates bound to F-box proteins become ubiquitinated. Here we show that Fbx2, a brain-enriched F-box protein implicated in the ubiquitination of glycoproteins discarded from the endoplasmic reticulum, binds t...
متن کاملF-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex
We have reconstituted the ubiquitination pathway for the Cdk inhibitor Sic1 using recombinant proteins. Skp1, Cdc53, and the F-box protein Cdc4 form a complex, SCFCdc4, which functions as a Sic1 ubiquitin-ligase (E3) in combination with the ubiquitin conjugating enzyme (E2) Cdc34 and E1. Cdc4 assembled with Skp1 functions as the receptor that selectively binds phosphorylated Sic1. Grr1, an F-bo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2006
ISSN: 0950-382X
DOI: 10.1111/j.1365-2958.2006.05215.x